Falsettos is the story of a large, eccentric, and dysfunctional -- but loving -- Jewish family in New York at the end of the 1970s. Initially, Marvin seems blessed with the perfect family. He has a caring wife, Trina and a young son, Jason. Nevertheless, the family is soon broken apart, when the homosexual Marvin leaves Trina for a man called Whizzer. 

Trina, meanwhile, ends up romantically involved with the family psychiatrist, Mendel. All the while, their son, Jason, is stuck in the middle. Included in the mix are lesbian neighbors Dr. Charlotte and Cordelia. When Marvin's lover, Whizzer, is diagnosed with AIDS, the entire family -- non-traditional as it may be -- must put aside their issues and come together.